![]() ![]() ![]() “Hypergenesis” means increase in number of cells/proliferation of cells. Nil –neuron,cardiac muscle ,skeletal muscle.High –epidermis, intestinal epithelium, hepatocytes, BM, fibroblasts.In cells with mitotic ability, both hyperplasia and hypertrophy can occur. It is due to excessive hormonal stimulation or it is the effect of growth factors on stem cells. Increase in size of uterus during pregnancy is also an example of hormonal hyperplasia.Īfter partial hepatectomy, if one lobe of liver is donated for transplant, organ grows back to its original size. proliferation of breasts, at puberty and during pregnancy, which is usually accompanied by hypertrophy of glandular epithelial cells. It increases the functional capability of tissue when needed e.g. Myocardial fibers are non-dividing and undergo hypertrophy only (cannot synthesize DNA).In wound healing, blood vessels and fibroblasts also undergo hyperplasia.Hyperplasia also occurs in response to certain viral infections like human papilloma causing warts.Benign prostatic hyperplasia occurs in response to androgens.Proliferation of glandular epithelium of female breasts at puberty and during pregnancy.Estrogen induced growth in uterus involves both increase in DNA synthesis and enlargement of smooth muscles during pregnancy.Though hyperplasia and hypertrophy are two different processes, but frequently they occur together and may be triggered by the same stimuli. It is an adaptive response of cell to excessive physiological or pathological stimuli and occurs in cellular population capable of synthesizing DNA, and thus permitting mitosis. Hyperplasia constitutes an increase in number of cells in an organ or tissue which may then have increased volume. ![]()
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